Cyclodextrin-based nanosponges for drug delivery

被引：204

作者：

Cavalli, Roberta

Trotta, Francesco

Tumiatti, Wander

机构：

[1] Univ Turin, UFM, Dipartimento Chim, I-10125 Turin, Italy

[2] Sea Marconi Technol, I-10097 Collegno, Italy

[3] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2006年 / 56卷 / 1-2期

关键词：

beta-cyclodextrin; drug delivery; inclusion complexes; nanoporous materials; nanosponges;

D O I：

10.1007/s10847-006-9085-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanosponges were prepared from beta-cyclodextrins as nanoporous materials for possible use as carriers for drug delivery. The structure of beta-cyclodextrin-based nanosponges was principally investigated by FT-IR, DSC and RX analyses. Sizes, morphology and toxicity were also examined. The capacity of the nanosponges to incorporate molecules within their structure was evaluated using drugs with different structures and solubilities. The nanosponges were found capable of carrying both lipophilic and hydrophilic drugs and of improving the solubility of poorly water-soluble molecules.

引用

页码：209 / 213

页数：5

共 8 条

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