Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15

被引：35

作者：

Adunyah, SE ^{[1
]}

Wheeler, BJ ^{[1
]}

Cooper, RS ^{[1
]}

机构：

[1] MEHARRY MED COLL,CTR COMPREHENS SICKLE CELL,NASHVILLE,TN 37208

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 232卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human IL-15 is a cytokine expressed by a variety of tissues and cells including myeloid progenitor cells and monocytes. It shares biologic properties of IL-2 and utilizes the beta subunit of the IL-BR, IL-15 regulates proliferation of activated B and Mt cells and stimulates chemoattraction in blood T-lymphocytes, effects which are inhibited by an anti-IL-SR beta antibody. Because little is known about the mechanism(s) by which IL-15 signal is transduced, this study was conducted to identify some of the key molecules involved in IL-15-induced signaling cascade(s). We report that IL-15 induces tyr phosphorylation of the p75IL-2R beta and p64IL-2R gamma subunits and She. Also, it activates both p561ck and MAPK (ERK-1). These results strongly suggest that LCK and MAPK may play vital roles in mediation of cellular activation by IL-15. (C) 1997 Academic Press.

引用

页码：754 / 758

页数：5

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