Mucin-type O-glycans and leukosialin

被引：55

作者：

Fukuda, M ^{[1
]}

Tsuboi, ST ^{[1
]}

机构：

[1] Burnham Inst, Canc Res Ctr, Glycobiol Program, La Jolla, CA 92037 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1999年 / 1455卷 / 2-3期

关键词：

mucin-type O-glycan; core; 2; branch; core 2 branching beta 1,6-N-acetylglucosaminyltransferase; cell adhesion;

D O I：

10.1016/S0925-4439(99)00067-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mucin-type O-glycans on leukocytes acquire functions once they contain core 2 branches, which can be synthesized by core 2 beta 1,6-N-acetylglucosaminyltransferase (C2GnT). Recently, understanding the roles of mucin-type O-glycans has been significantly advanced by generating transgenic mice overexpressing C2GnT or knockout mice defective in C2GnT. This review article summarizes previous results implicating the roles of mucin-type O-glycans and the most recent studies to test such a hypothesis. These results, taken together, demonstrate that mucin-type O-glycans either facilitate or attenuate cell adhesion depending on the structures of non-reducing termini. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：205 / 217

页数：13

共 81 条

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