Acute promyelocytic leukemia developing in untreated essential thrombocythemia

被引：5

作者：

Sato, N

Furukawa, T

Masuko, M

Hashimoto, S

Takahashi, H

Baba, M

Inano, K

Suzuki, N

Toba, K

Fuse, I

Aizawa, Y

机构：

[1] Niigata Univ, Hosp Med, Div Bone Marrow Transplantat, Niigata 9518520, Japan

[2] Niigata Univ, Sch Med, Dept Internal Med 1, Niigata, Japan

[3] Niigata Univ, Hosp Med, Clin Lab Div, Niigata 9518520, Japan

[4] Niigata Univ, Hosp Med, Div Blood Transfus, Niigata 9518520, Japan

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2002年 / 71卷 / 02期

关键词：

essential thrombocythemia; acute promyelocytic leukemia; acute transformation; peripheral blood stem cell transplantation; myeloproliferative disease;

D O I：

10.1002/ajh.10195

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a patient with untreated essential thrombocythemia (ET) who developed microgranular variant of acute promyelocytic leukemia, 9 years after the initial diagnosis of ET. He achieved complete remission (CR) but relapsed 11 months later. After achieving the second CR, he received peripheral stem cell transplantation from his HLA complete-matched sibling. Five months after the transplantation, he relapsed again with meningeal infiltration of leukemic cells. In this paper, we review cases of promyelocytic transformation of myeloproliferative diseases (MPD) other than chronic myeloid leukemia (CML). To our knowledge, this is the first case of promyelocytic transformation of Philadelphia chromosome negative untreated ET, in whom both t(15;17) and PML-RARalpha fusion were proven. (C) 2002 Wiley-Liss, Inc.

引用

页码：114 / 116

页数：3

共 14 条

[1] Acute promyelocytic leukemia in a patient with idiopathic myelofibrosis [J].