Hypophosphatemia: the common denominator of all rickets

被引：156

作者：

Tiosano, Dov ^{[1
,2
]}

Hochberg, Ze'ev ^{[1
,2
]}

机构：

[1] Meyer Childrens Hosp, Rambam Med Ctr, IL-31096 Haifa, Israel

[2] Technion Israel Inst Technol, Rappaport Family Fac Med & Res Inst, Haifa, Israel

来源：

JOURNAL OF BONE AND MINERAL METABOLISM | 2009年 / 27卷 / 04期

关键词：

Hypophosphatemia; Rickets; Osteomalacia; Sodium phosphorous transporters; VITAMIN-D; PHOSPHATE COTRANSPORTER; INORGANIC-PHOSPHATE; DENTS-DISEASE; IN-VIVO; BONE; MUTATIONS; APOPTOSIS; FGF23; GENE;

D O I：

10.1007/s00774-009-0079-1

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia-a derived defect in terminal chondrocyte apoptosis. This highlights the critical role of phosphorous in cartilage and bone metabolism. This review shows the role of phosphorous metabolism, transport and function in maintaining phosphorous supply to the growth plate, bone osteoblast and the kidney. Given that phosphorous is the common denominator of all rickets, this review proposes a new classification for the differential diagnosis of rickets, which is based on the mechanisms leading to hypophosphatemia-high PTH activity, high FGF23 activity or renal phosphaturia.

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收藏

页码：392 / 401

页数：10

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