Specificity of human antibodies reactive with pneumococcal C polysaccharide

被引：12

作者：

Frasch, CE ^{[1
]}

Concepcion, NF ^{[1
]}

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Lab Bacterial Polysaccharides, Bethesda, MD USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 04期

关键词：

D O I：

10.1128/IAI.68.4.2333-2337.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Antibodies reactive with C polysaccharide (PS) were found in healthy adults, pneumococcal patients, and vaccinees. These antibodies were not directed to the phosphocholine determinant of the C PS, as they appear to be in mice, since the human antibodies were inhibitable only with C PS. We found another population of phosphocholine-specific antibodies inhibitable only by phosphocholine and related compounds.

引用

页码：2333 / 2337

页数：5

共 17 条

[1]

ANTIPNEUMOCOCCAL EFFECTS OF C-REACTIVE PROTEIN AND MONOCLONAL-ANTIBODIES TO PNEUMOCOCCAL CELL-WALL AND CAPSULAR ANTIGENS [J].

BRILES, DE ;

FORMAN, C ;

HOROWITZ, JC ;

VOLANAKIS, JE ;

BENJAMIN, WH ;

MCDANIEL, LS ;

ELDRIDGE, J ;

BROOKS, J .

INFECTION AND IMMUNITY, 1989, 57 (05) :1457-1464

[2]

NATURALLY-OCCURRING ANTIBODIES TO PHOSPHOCHOLINE AS A POTENTIAL INDEX OF ANTIBODY RESPONSIVENESS TO POLYSACCHARIDES [J].

BRILES, DE ;

SCOTT, G ;

GRAY, B ;

CRAIN, MJ ;

BLAESE, M ;

NAHM, M ;

SCOTT, V ;

HABER, P .

JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (06) :1307-1314

[3]

BROWN M, 1984, J IMMUNOL, V132, P1323

[4]

Evaluation of previously assigned antibody concentrations in pneumococcal polysaccharide reference serum 89SF by the method of cross-standardization [J].

Concepcion, N ;

Frasch, CE .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1998, 5 (02) :199-204

[5]

TEICHOIC-ACID AND LIPOTEICHOIC ACID OF STREPTOCOCCUS-PNEUMONIAE POSSESS IDENTICAL CHAIN STRUCTURES - A REINVESTIGATION OF TEICHOID ACID (C-POLYSACCHARIDE) [J].

FISCHER, W ;

BEHR, T ;

HARTMANN, R ;

PETERKATALINIC, J ;

EGGE, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 215 (03) :851-857

[6]

The immunological properties of the heterophile antigen and somatic polysaccharide of pneumococcus [J].

Goebel, WF ;

Adams, MH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1943, 77 (05) :435-449

[7]

EPIDEMIOLOGICAL-STUDIES OF STREPTOCOCCUS-PNEUMONIAE IN INFANTS - DEVELOPMENT OF ANTIBODY TO PHOSPHOCHOLINE [J].

GRAY, BM ;

DILLON, HC ;

BRILES, DE .

JOURNAL OF CLINICAL MICROBIOLOGY, 1983, 18 (05) :1102-1107

[8]

STRUCTURE OF THE COMPLEX POLYSACCHARIDE C-SUBSTANCE FROM STREPTOCOCCUS-PNEUMONIAE TYPE-1 [J].

JENNINGS, HJ ;

LUGOWSKI, C ;

YOUNG, NM .

BIOCHEMISTRY, 1980, 19 (20) :4712-4719

[9]

The pneumococcal common antigen C-polysaccharide occurs in different forms - Mono-substituted or di-substituted with phosphocholine [J].

Karlsson, C ;

Jansson, PE ;

Sorensen, UBS .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 265 (03) :1091-1097

[10]

SERUM ANTIBODIES TO PNEUMOCOCCAL-C POLYSACCHARIDE IN CHILDREN - RESPONSE TO ACUTE PNEUMOCOCCAL OTITIS-MEDIA OR TO VACCINATION [J].

KOSKELA, M .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1987, 6 (06) :519-526

← 1 2 →