The role of basement membrane proteins on the expression of neural cell adhesion molecule (N-CAM) in an adenoid cystic carcinoma cell line

被引：29

作者：

França, CM ^{[1
]}

Jaeger, MMM ^{[1
]}

Jaeger, RG ^{[1
]}

Araújo, NS ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, BR-05508900 Sao Paulo, Brazil

来源：

ORAL ONCOLOGY | 2000年 / 36卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

adenoid cystic carcinoma; basement membrane; cell culture; immunofluorescence; N-CAM; salivary gland rumours;

D O I：

10.1016/S1368-8375(99)00087-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type 1V collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. Control cells presented a scattered N-CAM expression on cell membrane. and type IV collagen had no effect in N-CAM distribution. CAC2 cells grown on laminin-coated coverslips expressed N-CAM concentrated on cell lamellipodia suggesting relationship with migratory activity. Our results showed that cultured adenoid cystic carcinoma cells express N-CAM and this expression is modulated by extracellular matrix. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：248 / 252

页数：5

共 21 条

[1]

AMOS LA, 1991, MOL CYTOSLELETO, P80

[2]

CHENG J, 1992, CANCER, V69, P2631, DOI 10.1002/1097-0142(19920601)69:11<2631::AID-CNCR2820691103>3.0.CO

[3]

2-P

[4] CELL-ADHESION MOLECULES AS MORPHOREGULATORS [J].

CUNNINGHAM, BA .

CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (05) :628-633

[5]

Franca CM, 1997, J DENT RES, V76, P1001

[6] DIFFERENT EXTRACELLULAR DOMAINS OF THE NEURAL CELL-ADHESION MOLECULE (N-CAM) ARE INVOLVED IN DIFFERENT FUNCTIONS [J].

FREI, T ;

HALBACH, FV ;

WILLE, W ;

SCHACHNER, M .

JOURNAL OF CELL BIOLOGY, 1992, 118 (01) :177-194

[7] Neural cell adhesion molecule in adenoid cystic carcinoma invading the skull base [J].

GandourEdwards, R ;

Kapadia, SB ;

Barnes, L ;

Donald, PJ ;

Janecka, IP .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1997, 117 (05) :453-458

[8]

JIN L, 1991, AM J PATHOL, V138, P961

[9] Adenoid cystic carcinoma of the head and neck [J].

Jones, AS ;

Hamilton, JW ;

Rowley, H ;

Husband, D ;

Helliwell, TR .

CLINICAL OTOLARYNGOLOGY, 1997, 22 (05) :434-443

[10]

LOYOLA AM, 1995, ORAL ONCOL, V31B, P197

← 1 2 3 →