The emerging complexity of the vertebrate cilium: New functional roles for an ancient organelle

被引：98

作者：

Davis, Erica E.

Brueckner, Martina

Katsanis, Nicholas ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[2] Yale Univ, Sch Med, Dept Pediat Cardiol, New Haven, CT 06520 USA

来源：

DEVELOPMENTAL CELL | 2006年 / 11卷 / 01期

关键词：

D O I：

10.1016/j.devcel.2006.06.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cilia and flagella are found on the surface of a strikingly diverse range of cell types. These intriguing organelles, with their unique and highly adapted protein transport machinery, have been studied extensively in the context of cellular locomotion, sexual reproduction, or fluid propulsion. However, recent studies are beginning to show that in vertebrates particularly, cilia have been recruited to perform additional developmental and homeostatic roles. Here, we review advances in deciphering the functional components of cilia, and we explore emerging trends that implicate ciliary proteins in signal transduction and morphogenetic pathways.

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收藏

页码：9 / 19

页数：11

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