A viscoelastic model of phagosome motion within cells based on cytomagnetometric measurements

被引:13
作者
Nemoto, I [1 ]
Moeller, W
机构
[1] Tokyo Denki Univ, Dept Math Sci, Hatoyama, Saitama 3500394, Japan
[2] GSF Natl Res Ctr Environm & Hlth, D-82131 Gauting, Germany
关键词
biomagnetism; cytomagnetometry; cytoplasmic properties; cytoskeleton; intracellular motility;
D O I
10.1109/10.821751
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Cytomagnetometry is a noninvasive method to investigate intracellular movements of organelles such as phagosomes by introducing magnetic particles into cells by phagocytosis, magnetizing them and measuring the field from the cells, To analyze the results of the cell-field measurement, we introduce a model for intracellular phagosome motion and in investigate their behavior in terms of the cell field, The model includes an elastic body and two viscosity components which are ascribed to the filamentous structures surrounding the phagosomes. The magnetic relaxation phenomenon is assumed to derive from the rotationary Brownian motion as in our previous model. Although the model is simple, its behavior is not trivial because it contains a nonlinear term and the Brownian motion term. This model is the simplest one possible having a viscoelastic body and its behavior hence should be investigated thoroughly.
引用
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页码:170 / 182
页数:13
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