Prevalence and severity of allergic rhinitis in house dust mite-allergic patients with bronchial asthma or atopic dermatitis

被引:54
作者
Terreehorst, I
Oosting, AJ
Tempels-Pavlica, Z
de Monchy, JGR
Bruijnzeel-Koomen, CAFM
Hak, E
van Wijk, RG
机构
[1] Univ Hosp, Dept Allergol, Rotterdam, Netherlands
[2] Albert Schweitzer Hosp, Dept Internal Med, Dordrecht, Netherlands
[3] Univ Med Ctr, Dept Dermatol, Utrecht, Netherlands
[4] Univ Hosp, Dept Allergol, Groningen, Netherlands
[5] Univ Med Ctr, Julius Ctr, Utrecht, Netherlands
关键词
allergic rhinitis; allergy; atopic dermatitis; bronchial asthma; comorbidity; house dust mite;
D O I
10.1046/j.1365-2745.2002.01461.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background Allergic rhinitis, asthma and atopic dermatitis are closely associated. Although population-based studies report a high prevalence of rhinitis among asthma patients, less is known of the association between rhinitis and atopic dermatitis and the severity of concomitant rhinitis. Objectives We aimed to determine the prevalence and severity of allergic rhinitis among asthmatics and patients with atopic dermatitis and assessed whether age and comorbidity influence the severity of rhinitis signs and symptoms. Methods Three hundred and twenty-five patients recruited for a multicentre trial to study the effect of encasings of mattresses, pillows and duvets on signs and symptoms of allergic rhinitis and/or asthma and/or atopic dermatitis recorded visual analogue scores (VAS) and daily symptom scores and underwent nasal challenge tests with house dust mite (HDM). Results Based on history and clinical symptoms 92% of the 164 asthmatic patients and 85% of the 86 patients with atopic dermatitis could be diagnosed as having rhinitis. Inclusion of a positive provocation to HDM did not result in a substantial lower prevalence of rhinitis. Subjects reported moderate symptoms, with mean rhinitis VAS scores ranging from 40.0 to 55.0. Presence of atopic dermatitis was associated with lower rhinitis VAS and symptoms scores, whereas in multivariate analysis the presence of asthma was positively associated with nasal responsiveness to HDM. Conclusion The prevalence of nasal symptoms in patients with bronchial asthma or atopic dermatitis and sensitized to house dust mites is high. Although the majority of patients experience mild to moderate symptoms, the presence of nasal disease needs to be examined in all patients with atopic disorders.
引用
收藏
页码:1160 / 1165
页数:6
相关论文
共 22 条
[1]  
[Anonymous], ACTA DERM VENERE S92, DOI [10.2340/00015555924447, DOI 10.2340/00015555924447]
[2]   DIFFERENT EFFECTS OF NASAL AND BRONCHIAL GLUCOCORTICOSTEROID ADMINISTRATION ON BRONCHIAL HYPERRESPONSIVENESS IN PATIENTS WITH ALLERGIC RHINITIS [J].
AUBIER, M ;
LEVY, J ;
CLERICI, C ;
NEUKIRCH, F ;
HERMAN, D .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (01) :122-126
[3]   New directions in allergic diseases: Mechanism-based anti-inflammatory therapies [J].
Barnes, PJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (01) :5-16
[4]   Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study [J].
Blom, HM ;
VanRijswijk, JB ;
Garrelds, IM ;
Mulder, PGH ;
Timmermans, T ;
VanWijk, RG .
CLINICAL AND EXPERIMENTAL ALLERGY, 1997, 27 (07) :796-801
[5]   ASSESSMENT OF QUALITY-OF-LIFE IN PATIENTS WITH PERENNIAL ALLERGIC RHINITIS WITH THE FRENCH VERSION OF THE SF-36 HEALTH-STATUS QUESTIONNAIRE [J].
BOUSQUET, J ;
BULLINGER, M ;
FAYOL, C ;
MARQUIS, P ;
VALENTIN, B ;
BURTIN, B .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (02) :182-188
[6]   Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients [J].
Braunstahl, GJ ;
Kleinjan, A ;
Overbeek, SE ;
Prins, JB ;
Hoogsteden, HC ;
Fokkens, WJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (06) :2051-2057
[7]   CHANGES IN BRONCHIAL RESPONSIVENESS FOLLOWING NASAL PROVOCATION WITH ALLERGEN [J].
CORREN, J ;
ADINOFF, AD ;
IRVIN, CG .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (02) :611-618
[8]  
De Graaf-In't Veld C., 1995, Clinical and Experimental Allergy, V25, P966, DOI 10.1111/j.1365-2222.1995.tb00399.x
[9]   ALLERGY IN 7000 TWIN PAIRS [J].
EDFORSLUBS, ML .
ACTA ALLERGOLOGICA, 1971, 26 (04) :249-+
[10]   Measurement of disease activity and outcome in atopic dermatitis [J].
Finlay, AY .
BRITISH JOURNAL OF DERMATOLOGY, 1996, 135 (04) :509-515