RNA polymerase beta' subunit: A target of DNA binding-independent activation

被引：58

作者：

Miller, A

Wood, D

Ebright, RH

RothmanDenes, OB

机构：

[1] UNIV CHICAGO,DEPT MOL GENET & CELL BIOL,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOL BIOL,CHICAGO,IL 60637

[3] RUTGERS STATE UNIV,DEPT CHEM,NEW BRUNSWICK,NJ 08855

[4] RUTGERS STATE UNIV,WAKSMAN INST,NEW BRUNSWICK,NJ 08855

来源：

SCIENCE | 1997年 / 275卷 / 5306期

关键词：

D O I：

10.1126/science.275.5306.1655

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The bacteriophage N4 single-stranded DNA binding protein (N4SSB) activates transcription by the Escherichia coli sigma 70-RNA polymerase at N4 late promoters. Here it is shown that the single-stranded DNA binding activity of N4SSB is not required for transcriptional activation. N4SSB interacts with the carboxyl terminus of the RNA polymerase beta' subunit in a region that is highly conserved in the largest subunits of prokaryotic and eukaryotic RNA polymerases.

引用

页码：1655 / 1657

页数：3

共 38 条

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