Inositol polyphosphate 5-phosphatases: Lipid phosphatases with flair

被引:46
作者
Mitchell, CA [1 ]
Gurung, R [1 ]
Kong, AM [1 ]
Dyson, JM [1 ]
Tan, A [1 ]
Ooms, LM [1 ]
机构
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
关键词
actin cytoskeleton; B cell proliferation; calcium signaling; inositol; 5-phosphatase; insulin signaling; vesicle trafficking;
D O I
10.1080/15216540210815
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.
引用
收藏
页码:25 / 36
页数:12
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