Global cell sorting is mediated by local cell-cell interactions in the C-elegans embryo

被引：28

作者：

Bischoff, Marcus ^{[1
]}

Schnabel, Ralf ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Genet, D-38106 Braunschweig, Germany

来源：

DEVELOPMENTAL BIOLOGY | 2006年 / 294卷 / 02期

关键词：

cell-cell interactions; cell movements; pattern formation; cell sorting; 4D microscopy; cell polarity;

D O I：

10.1016/j.ydbio.2006.03.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Caenorhabditis elegans embryo achieves pattern formation by sorting cells into coherent regions before morphogenesis is initiated. The sorting of cells is coupled to their fate. Cells move extensively relative to each other to reach their correct position in the body plan. Analyzing the mechanism of cell sorting in in vitro culture experiments using 4D microscopy, we show that all AB-derived cells sort only according to their local neighbors, and that all cells are able to communicate with each other. The directions of cell movement do not depend on a cellular polarity but only on local cell-cell interactions; in experimental situations, this allows even the reversal of the polarity of whole regions of the embryo. The work defines a new mechanism of pattern formation we call "cell focusing". (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：432 / 444

页数：13

共 23 条

[1]

BISCHOFF M, UNPUB POSTERIOR CTR

[2]

BRENNER S, 1974, GENETICS, V77, P71

[3] Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome [J].

Cortés, F ;

Daggett, D ;

Bryson-Richardson, RJ ;

Neyt, C ;

Maule, J ;

Gautier, P ;

Hollway, GE ;

Keenan, D ;

Currie, PD .

DEVELOPMENTAL CELL, 2003, 5 (06) :865-876

[4] Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants [J].

Duguay, D ;

Foty, RA ;

Steinberg, MS .

DEVELOPMENTAL BIOLOGY, 2003, 253 (02) :309-323

[5]

Edgar LG, 1995, METHOD CELL BIOL, V48, P303

[6] THE POTENTIAL TO DIFFERENTIATE EPIDERMIS IS UNEQUALLY DISTRIBUTED IN THE AB LINEAGE DURING EARLY EMBRYONIC-DEVELOPMENT IN C-ELEGANS [J].

GENDREAU, SB ;

MOSKOWITZ, IPG ;

TERNS, RM ;

ROTHMAN, JH .

DEVELOPMENTAL BIOLOGY, 1994, 166 (02) :770-781

[7] Drosophila oocyte localization is mediated by differential cadherin-based adhesion [J].

Godt, D ;

Tepass, U .

NATURE, 1998, 395 (6700) :387-391

[8] CELL CONTACTS ORIENT SOME CELL-DIVISION AXES IN THE CAENORHABDITIS-ELEGANS EMBRYO [J].

GOLDSTEIN, B .

JOURNAL OF CELL BIOLOGY, 1995, 129 (04) :1071-1080

[9]

González-Reyes A, 1998, DEVELOPMENT, V125, P3635

[10] Axis determination in C-elegans:: initiating and transducing polarity [J].

Gotta, M ;

Ahringer, J .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (04) :367-373

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