Malaria and macrophage function in Africans: A possible link with autoimmune disease?

被引：10

作者：

Butcher, GA

机构：

[1] Department of Biology, Imp. Coll. Sci., Technol. and Med., London SW7 2BB, Prince Consort Road

来源：

MEDICAL HYPOTHESES | 1996年 / 47卷 / 02期

关键词：

D O I：

10.1016/S0306-9877(96)90446-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Systemic lupus erythematosus and sarcoidosis, both diseases in which immune reponses are aberrant, are not found in Africans in West Africa, but their prevalence in people of West African descent in the USA and UK is higher than that for white people. It is argued here that malaria both prevents these diseases in West Africa by its effects on macrophage function, and has also selected for a predisposition to them.

引用

页码：97 / 100

页数：4

共 35 条

[1] IN-VITRO PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA BY ADHERENT HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS INCUBATED WITH KILLED COCCIDIOIDAL ARTHROCONIDIA AND SPHERULES [J].