The inhibition of γ-secretase as a therapeutic approach to Alzheimer's disease

被引：26

作者：

Tomita, T ^{[1
]}

Iwatsubo, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

DRUG NEWS & PERSPECTIVES | 2004年 / 17卷 / 05期

关键词：

D O I：

10.1358/dnp.2004.17.5.829036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer's disease is a dementing neurodegenerative disorder for which there is no effective treatment at present. Genetic and biological studies provide evidence that the production and deposition of amyloid-beta peptides (Abeta) contribute to the etiology of Alzheimer's disease. gamma-Secretase is the pivotal enzyme in generating the C terminus of Abeta, which determines its aggregability and speed of deposition. Drugs that regulate the production of Abeta by inhibiting gamma-secretase activity could provide an effective therapy for Alzheimer's disease, although recent studies suggest that gamma-secretase plays important roles in cellular signaling. This review focuses on studies of the gamma-secretase biology and provides the direction for developing effective and selective gamma-secretase inhibitors as drugs for the treatment of Alzheimer's disease. (C) 2004 Prous Science. All rights reserved.

引用

页码：321 / 325

页数：5

共 33 条

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