IMAGING MASS SPECTROMETRY: INSTRUMENTATION, APPLICATIONS, AND COMBINATION WITH OTHER VISUALIZATION TECHNIQUES

被引：153

作者：

Bodzon-Kulakowska, Anna ^{[1
]}

Suder, Piotr ^{[1
,2
]}

机构：

[1] AGH Univ Sci & Technol, Dept Biochem & Neurobiol, Fac Mat Sci & Ceram, Mickiewicza 30 Ave, PL-30059 Krakow, Poland

[2] AGH Univ Sci & Technol, Acad Ctr Mat & Nanotechnol ACMiN, PL-30059 Krakow, Poland

来源：

MASS SPECTROMETRY REVIEWS | 2016年 / 35卷 / 01期

关键词：

mass spectrometry imaging; DESI; MALDI; SIMS; DESORPTION ELECTROSPRAY-IONIZATION; PARAFFIN-EMBEDDED TISSUE; PROTEOMIC ANALYSIS; BIOLOGICAL TISSUE; PROTEIN IDENTIFICATION; SPATIAL-RESOLUTION; SAMPLE PREPARATION; DRUG DISTRIBUTION; LIPID SIGNATURES; CANCER TISSUES;

D O I：

10.1002/mas.21468

中图分类号：

O433 [光谱学];

学科分类号：

070207 [光学];

摘要：

Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It has unique ability to identify structures and to unravel molecular changes that occur in the precisely defined part of the sample. These unique features open new possibilities in the field of various aspects of biological research. In this review we briefly discuss the main imaging mass spectrometry techniques, as well as the nature of biological samples and molecules, which might be analyzed by such methodology. Moreover, a novel approach, where different analytical techniques might be combined with the results of IMS study, is emphasized and discussed. With such a fast development of IMS and related methods, we can foresee the promising future of this technique. (c) 2015 Wiley Periodicals, Inc.

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收藏

页码：147 / 169

页数：23

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