Telomerase as a possible target for anticancer therapy

被引：31

作者：

Autexier, C ^{[1
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Bloomfield Ctr Res Aging, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2B4, Canada

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 11期

关键词：

D O I：

10.1016/S1074-5521(99)80122-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chromosomes. The enzyme telomerase is one mechanism that maintains telomeres, and is activated in 85% of human cancer cells. New studies on peptide nucleic acids (PNAs) that inhibit telomerase have demonstrated that unexpected regions of the enzyme can serve as targets for inhibitors. The novel delivery method used expands the utility of PNAs.

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页码：R299 / R303

页数：5

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