Telomerase as a possible target for anticancer therapy

被引：31

作者：

Autexier, C ^{[1
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Bloomfield Ctr Res Aging, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2B4, Canada

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 11期

关键词：

D O I：

10.1016/S1074-5521(99)80122-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chromosomes. The enzyme telomerase is one mechanism that maintains telomeres, and is activated in 85% of human cancer cells. New studies on peptide nucleic acids (PNAs) that inhibit telomerase have demonstrated that unexpected regions of the enzyme can serve as targets for inhibitors. The novel delivery method used expands the utility of PNAs.

引用

收藏

页码：R299 / R303

页数：5

相关论文

共 60 条

[31] A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo [J].

Mata, JE ;

Joshi, SS ;

Palen, B ;

Pirruccello, SJ ;

Jackson, JD ;

Elias, N ;

Page, TJ ;

Medlin, KL ;

Iversen, PL .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1997, 144 (01) :189-197

[32] Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides [J].

Matthes, E ;

Lehmann, C .

NUCLEIC ACIDS RESEARCH, 1999, 27 (04) :1152-1158

[33] RUNAWAY TELOMERE ELONGATION CAUSED BY TELOMERASE RNA GENE-MUTATIONS [J].

MCEACHERN, MJ ;

BLACKBURN, EH .

NATURE, 1995, 376 (6539) :403-409

[34] THE HUMAN TELOMERE TERMINAL TRANSFERASE ENZYME IS A RIBONUCLEOPROTEIN THAT SYNTHESIZES TTAGGG REPEATS [J].

MORIN, GB .

CELL, 1989, 59 (03) :521-529

[35]

Müller A, 1998, ADV EXP MED BIOL, V451, P23

[36] Telomerase catalytic subunit homologs from fission yeast and human [J].

Nakamura, TM ;

Morin, GB ;

Chapman, KB ;

Weinrich, SL ;

Andrews, WH ;

Lingner, J ;

Harley, CB ;

Cech, TR .

SCIENCE, 1997, 277 (5328) :955-959

[37] Two modes of survival of fission yeast without telomerase [J].

Nakamura, TM ;

Cooper, JP ;

Cech, TR .

SCIENCE, 1998, 282 (5388) :493-496

[38] Inhibition of human telomerase activity by peptide nucleic acids [J].

Norton, JC ;

Piatyszek, MA ;

Wright, WE ;

Shay, JW ;

Corey, DR .

NATURE BIOTECHNOLOGY, 1996, 14 (05) :615-619

[39] The telomerase reverse transcriptase: components and regulation [J].

Nugent, CI ;

Lundblad, V .

GENES & DEVELOPMENT, 1998, 12 (08) :1073-1085

[40]

Ohnuma T, 1997, ANTICANCER RES, V17, P2455

← 1 2 3 4 5 6 →