Synthesis of aminoglycoside-DNA conjugates

被引：46

作者：

Charles, I ^{[1
]}

Xue, LA ^{[1
]}

Arya, DP ^{[1
]}

机构：

[1] Clemson Univ, Dept Chem, Lab Med Chem, Clemson, SC 29634 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 09期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(02)00157-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1259 / 1262

页数：4

共 26 条

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