High-throughput preparative separations from combinatorial libraries

被引：6

作者：

Coleman, K ^{[1
]}

机构：

[1] Anachem Ltd, Luton LU2 0EB, Beds, England

来源：

ANALUSIS | 1999年 / 27卷 / 08期

关键词：

SFC; fast gradient; combinatorial libraries; drug discovery; purification;

D O I：

10.1051/analusis:1999270719

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Guidelines for high-throughput preparative separations with SFC methods are presented. Examples showing the use of generic modifier gradients and a single column can be successfully applied to cope with the large number of samples generated by combinatorial and medicinal chemists. The result is rapid achievement of high-purity analytes at the tens-of-milligram levels in a concentrated liquid form.

引用

页码：719 / 723

页数：5