Grey matter pathology in clinically early multiple sclerosis: Evidence from magnetic resonance imaging

被引：82

作者：

Chard, Declan ^{[1
]}

Miller, David ^{[1
]}

机构：

[1] UCL, Inst Neurol, Dept Neuroinflammat, NMR Res Unit, London WC1N 3BG, England

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2009年 / 282卷 / 1-2期

关键词：

Multiple sclerosis; Clinically isolated syndromes; Magnetic resonance imaging; Grey matter; VOXEL-BASED MORPHOMETRY; APPEARING WHITE-MATTER; PROTON MR SPECTROSCOPY; TRANSFER RATIO; FOLLOW-UP; METABOLITE CHANGES; CORTICAL ATROPHY; INTRACORTICAL LESIONS; COGNITIVE IMPAIRMENT; PREDICT CONVERSION;

D O I：

10.1016/j.jns.2009.01.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Multiple sclerosis (MS) it is emerging that the most visible element of pathology, white matter (WM) lesions, represents only a fraction of the disease burden borne by the brain; non-lesional WM is also damaged, as is the grey matter (GM). Evidence is also accruing that GM damage may be a major determinant of longer-term outcomes in MS, and that such damage occurs from the earliest clinical stages of the disease. In this review, we focus on the early stages of relapse onset MS, considering the nature, extent and evolution of GM pathology, as determined using magnetic resonance imaging. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：5 / 11

页数：7

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