Changes in the septohippocampal cholinergic system following removal of molar teeth in the aged SAMP8 mouse

被引：63

作者：

Onozuka, M

Watanabe, K

Fujita, M

Tomida, M

Ozono, S

机构：

[1] Gifu Univ, Sch Med, Dept Anat, Div 2, Gifu 5008705, Japan

[2] Gifu Univ, Sch Med, Dept Physiol, Gifu 5008705, Japan

[3] Kanagawa Dent Coll, Inst Frontier Oral Sci, Yokosuka, Kanagawa 2388580, Japan

来源：

BEHAVIOURAL BRAIN RESEARCH | 2002年 / 133卷 / 02期

关键词：

mastication; aging; hippocampus; cholinergic system; acetylcholine; septal nucleus;

D O I：

10.1016/S0166-4328(02)00006-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We investigated the effect of dysfunctional teeth on age-related changes in the septohippocampal cholinergic system by assessing acetylcholine (ACh) release and choline acetyltransferase (ChAT) activity in the hippocampus and ChAT immunohistochemistry in the medial septal nucleus and the vertical limb of the diagonal band in young-adult and aged SAMP8 mice after removal of their upper molar teeth (molarless condition). Aged molarless mice showed decreased ACh release and ChAT activity in the hippocampus and a reduced number of ChAT-immunopositive neurons in the medial serial nucleus compared to age-matched control mice, whereas these effects were not seen in young-adult mice. The results suggest that the molarless condition in aged SAMP8 mice may enhance an age-related decline in the septohippocampal cholinergic system. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：197 / 204

页数：8

共 44 条

[1] AN ANALYSIS OF THE ORIGINS OF THE CHOLINERGIC AND NONCHOLINERGIC SEPTAL PROJECTIONS TO THE HIPPOCAMPAL-FORMATION OF THE RAT [J].