A novel microbial metabolite, activator of low density lipoprotein receptor promoter

被引：32

作者：

Hegde, VR

Puar, MS

Dai, P

Patel, M

Gullo, VP

Das, PR

Bond, RW

McPhail, AT

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

[2] Duke Univ, Dept Chem, PM Gross Chem Lab, Durham, NC 27708 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(99)02291-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The organic extract of the fermentation broth of a Micromonospora microorganism was found to contain SCH 351448 (1), the monosodium salt of a macrocyclic dilactone containing two identical diacids. The structure and relative stereochemistry were established by single-crystal X-ray analysis. SCH 351448 is a novel ionophoric compound and is a weak activator of low density lipoprotein receptor (LDL-R) promoter with an IC50 of 25 mu M. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1351 / 1354

页数：4

共 5 条

[1] AN ENZYME-LINKED IMMUNOSORBENT-ASSAY (ELISA) FOR URINARY GROWTH-HORMONE SUITABLE FOR USE IN THE ROUTINE LABORATORY - THE WESSEX GROWTH STUDY [J].