Oxidative stress to dopaminergic neurons as models of Parkinson's disease

被引：49

作者：

Gille, G

Hung, ST

Reichmann, H

Rausch, WD

机构：

[1] Vet Univ Vienna, Inst Med Chem, A-1210 Vienna, Austria

[2] Tech Univ Dresden, Dept Neurol, D-8027 Dresden, Germany

来源：

STRESS: CURRENT NEUROENDOCRINE AND GENETIC APPROACHES | 2004年 / 1018卷

关键词：

Parkinson's disease; oxidative stress; neuroprotection; dopamine agonists; coenzyme Q(10);

D O I：

10.1196/annals.1296.066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of exogenous toxins (MPP+, rotenone) and potentially neurotoxic properties of levodopa (L-DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP+-toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q(10) (CoQ(10)) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP+ is demonstrated.

引用

收藏

页码：533 / 540

页数：8

相关论文

共 19 条

[1] Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats [J].

Alam, M ;

Schmidt, WJ .

BEHAVIOURAL BRAIN RESEARCH, 2002, 136 (01) :317-324

[2] Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged [J].

Beal, MF ;

Matthews, RT ;

Tieleman, A ;

Shults, CW .

BRAIN RESEARCH, 1998, 783 (01) :109-114

[3] Neuroprotective effects of D3 dopamine receptor agonists [J].

Carvey, PM ;

McGuire, SO ;

Ling, ZD .

PARKINSONISM & RELATED DISORDERS, 2001, 7 (03) :213-223

[4] Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: Quinone oxidoreductase 1(NQO1) [J].

Chan, TS ;

Teng, S ;

Wilson, JX ;

Galati, G ;

Khan, S ;

O'Brien, PJ .

FREE RADICAL RESEARCH, 2002, 36 (04) :421-427

[5] Welcome news about levodopa, but uncertainty remains [J].

Fahn, S .

ANNALS OF NEUROLOGY, 1998, 43 (05) :551-554

[6] Pergolide protects dopaminergic neurons in primary culture under stress conditions [J].

Gille, G ;

Rausch, WD ;

Hung, ST ;

Moldzio, R ;

Janetzky, B ;

Hundemer, HP ;

Kolter, T ;

Reichmann, H .

JOURNAL OF NEURAL TRANSMISSION, 2002, 109 (5-6) :633-643

[7] Pergolide scavenges both hydroxyl and nitric oxide free radicals in vitro and inhibits lipid peroxidation in different regions of the rat brain [J].

Gómez-Vargas, M ;

Nishibayashi-Asanuma, S ;

Asanuma, M ;

Kondo, Y ;

Iwata, E ;

Ogawa, N .

BRAIN RESEARCH, 1998, 790 (1-2) :202-208

[8] Role of free radicals in the neurodegenerative diseases - Therapeutic implications for antioxidant treatment [J].

Halliwell, B .

DRUGS & AGING, 2001, 18 (09) :685-716

[9] QUANTITATIVE ENZYME-HISTOCHEMISTRY IN THE BRAIN [J].

KUGLER, P .

HISTOCHEMISTRY, 1988, 90 (02) :99-107

[10]

Langston JW, 1999, ANN NEUROL, V46, P598, DOI 10.1002/1531-8249(199910)46:4<598::AID-ANA7>3.0.CO