Mechanisms of spindle positioning:: focus on flies and worms

被引：69

作者：

Gönczy, P ^{[1
]}

机构：

[1] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0962-8924(02)02306-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate spindle positioning is crucial for spatial control of cell division. During metazoan development, coordination between polarity cues and spindle position also ensures correct segregation of cell fate determinants. Converging evidence indicates that spindle positioning is achieved through interactions between cortical anchors and the plus ends of microtubules, generating pulling forces acting on spindle poles. This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development.

引用

页码：332 / 339

页数：8

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