Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man

被引：214

作者：

Boube, M ^{[1
]}

Joulia, L ^{[1
]}

Cribbs, DL ^{[1
]}

Bourbon, HM ^{[1
]}

机构：

[1] Univ Toulouse 3, Ctr Dev Biol, F-31062 Toulouse, France

来源：

CELL | 2002年 / 110卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(02)00830-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits.

引用

页码：143 / 151

页数：9

共 58 条

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