Catalytic hydrogenation of N-t-butoxycarbonylindoles

被引：19

作者：

Coulton, S

Gilchrist, TL

Graham, K

机构：

[1] UNIV LIVERPOOL,DEPT CHEM,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(96)01021-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium catalysed hydrogenation of a range of N-t-butoxycarbonylindoles has been investigated. In most cases the hydrogenation proceeded smoothly at 200 psi in the presence of acetic acid to give the corresponding N-t-butoxycarbonyl-cis-2,3-dihydroindoles in high yield. Some indoles, in particular those bearing an acyl substituent at C-2 or at C-3, were not selectively reduced at the C-2-C-3 bond. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：791 / 798

页数：8

共 18 条

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