Health implications of nanoparticles

被引:211
作者
Kreyling, Wolfgang G.
Semmler-Behnke, Manuela
Moeller, Winfried
机构
[1] GSF Natl Res Ctr Environm & Hlth, Inst Inhalat Biol, D-85758 Neuherberg, Germany
[2] GSF Natl Res Ctr Environm & Hlth, Focus Network Aerosols & Hlth, D-85764 Neuherberg, Germany
[3] GSF Natl Res Ctr Environm & Hlth, Inflammatory Lung Dis, D-82131 Gauting, Germany
关键词
ultrafine particles; nanoparticles; health effects; particle dosimetry; epidemiological evidence; toxicological plausibility; environment; nanotechnology safety;
D O I
10.1007/s11051-005-9068-z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanoparticles are increasingly used in a wide range of applications in science, technology and medicine. Since they are produced for specific purposes which cannot be met by larger particles and bulk material they are likely to be highly reactive, in particular, with biological systems. On the other hand a large body of know-how in environmental sciences is available from toxicological effects of ultrafine particles (smaller than 100 nm in size) after inhalation. Since nanoparticles feature similar reactivity as ultrafine particles a sustainable development of new emerging nanoparticles is required. This paper gives a brief review on the dosimetry of nanoparticles, including deposition in the various regions of the respiratory tract and systemic translocation and uptake in secondary target organs, epidemiologic associations with health effects and toxicology of inhaled nanoparticles. General principles and current paradigms to explain for the specific behaviour of nanoparticles in toxicology are discussed. With that respect we consider nanoparticles to be in the range from 1 to 2 nm (clusters of atoms/molecules) to particles that are smaller than 100 nm at least in one dimension. Since the evidence for health risks of ultrafine and nanoparticles after inhalation has been increasing over the last decade, the paper attempts to extrapolate these findings and principles observed in particle inhalation toxicology into recommendations for an integrated concept of risk assessment of nanoparticles for a broad range of use in science, technology and medicine.
引用
收藏
页码:543 / 562
页数:20
相关论文
共 85 条
[1]  
[Anonymous], 1994, Ann ICRP, V24, P1
[2]   Particle deposition in a multiple-path model of the human lung [J].
Asgharian, B ;
Hofman, W ;
Bergmann, R .
AEROSOL SCIENCE AND TECHNOLOGY, 2001, 34 (04) :332-339
[3]   Neurogenic inflammation in the airways [J].
Barnes, PJ .
RESPIRATION PHYSIOLOGY, 2001, 125 (1-2) :145-154
[4]   Caveolae - An alternative endocytotic pathway for targeted drug delivery [J].
Bathori, G ;
Cervenak, L ;
Karadi, I .
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2004, 21 (02) :67-95
[5]  
Bodian D, 1941, B JOHNS HOPKINS HOSP, V69, P79
[6]   Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production [J].
Boland, S ;
Baeza-Squiban, A ;
Fournier, T ;
Houcine, O ;
Gendron, MC ;
Chévrier, M ;
Jouvenot, G ;
Coste, A ;
Aubier, M ;
Marano, F .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 276 (04) :L604-L613
[7]   Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells [J].
Boland, S ;
Bonvallot, V ;
Fournier, T ;
Baeza-Squiban, A ;
Aubier, M ;
Marano, F .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 278 (01) :L25-L32
[8]   Toxicological hazards of inhaled nanoparticles - Potential implications for drug delivery [J].
Borm, PJA ;
Kreyling, W .
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2004, 4 (05) :521-531
[9]   Air pollution and cardiovascular disease - A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association [J].
Brook, RD ;
Franklin, B ;
Cascio, W ;
Hong, YL ;
Howard, G ;
Lipsett, M ;
Luepker, R ;
Mittleman, M ;
Samet, J ;
Smith, SC ;
Tager, I .
CIRCULATION, 2004, 109 (21) :2655-2671
[10]   Transport of nanoparticles across the rat nasal mucosa [J].
Brooking, J ;
Davis, SS ;
Illum, L .
JOURNAL OF DRUG TARGETING, 2001, 9 (04) :267-279