Asymmetric induction by the (S)-1-phenylethyl group in intramolecular nitrile imine cycloadditions giving enantiopure 3,3a-dihydro-pyrazolo[1,5-α][1,4]benzodiazepine-4(6H)-ones

被引:18
作者
Broggini, G
Casalone, G
Garanti, L
Molteni, G
Pilati, T
Zecchi, G
机构
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] Univ Insubria, Dipartimento Sci Chim Fis & Matemat, I-22100 Como, Italy
[3] Univ Milan, CSRSRC, Ctr Studio Relaz Strutt & Reattiv Chim, I-20133 Milan, Italy
关键词
D O I
10.1016/S0957-4166(99)00493-0
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Stereoselective intramolecular cycloadditions of homochiral nitrile imines 5 are described as a fruitful source of enantiopure 3,3a-dihydro-pyrazolo[1,5-a][1,4]benzodiazepine-4(6H)-ones 6 and 7. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码:4447 / 4454
页数:8
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