Metabolic profiles of cancer cells

被引：568

作者：

Griffin, JL

Shockcor, JP

机构：

[1] Bruker Biospin, Billerica, MA 01821 USA

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrc1390

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the post-genomic era, several profiling tools have been developed to provide a more comprehensive picture of tumour development and progression. The global analysis of metabolites, such as by mass spectrometry and high-resolution H-1 nuclear magnetic resonance spectroscopy, can be used to define the metabolic phenotype of cells, tissues or organisms. These 'metabolomic' approaches are providing important information about tumorigenesis, revealing new therapeutic targets and will be an important component of automated diagnosis.

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收藏

页码：551 / 561

页数：11

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