Genetics of endometriosis: heritability and candidate genes

被引：41

作者：

Bischoff, F ^{[1
]}

Simpson, JL ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2004年 / 18卷 / 02期

关键词：

candidate genes; endometriosis; heritability; multihit;

D O I：

10.1016/j.bpobgyn.2004.01.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Endometriosis is a complex gynecologic disorder that affects as many as 10-15% of premenopausal women. Epidemiologic studies have confirmed that this disease is a genetic disorder of polygenic/multifactorial inheritance. The disorder has long been recognized to show heritable tendencies with recurrence risks of 5-7% for first-degree relatives. The current investigational goal is to determine the number and location of causative genes, a process that has been made possible by recent advances in molecular technology. This chapter discusses heritability studies supporting polygenic/multifactorial inheritance, the scientific basis of genome-wide strategies for identifying causative genes and potential candidate genes.

引用

页码：219 / 232

页数：14

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