Quantitative analysis of nociceptin in blood of patients with acute and chronic pain

被引：41

作者：

Ko, MH

Kim, YH

Woo, RS

Kim, KW ^{[1
]}

机构：

[1] Chonnam Natl Univ, Sch Med, Inst Med Sci, Dept Pharmacol, Chonju 561180, Chonbuk, South Korea

[2] Chonnam Natl Univ, Sch Med, Dept Rehabil Med, Chonju 561180, Chonbuk, South Korea

[3] Chonnam Natl Univ, Sch Med, Res Inst Clin Med, Chonju 561180, Chonbuk, South Korea

来源：

NEUROREPORT | 2002年 / 13卷 / 13期

关键词：

acute pain; chronic pain; human blood; nociceptin; radioimmunoassay;

D O I：

10.1097/00001756-200209160-00012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study aimed to define the change of serum level of nociceptin in pain patients. Seventy pain patients and 20 normal healthy subjects were enrolled. Patients were divided into three groups according to the duration of pain; (1) acute (within 4 weeks), (2) subacute (4 weeks to 6 months), and (3) chronic (> 6 months) state. Serum concentration of nociceptin was measured by radioimmunoassay. Serum nociceptin level was significantly higher in the patients with pain than in normal healthy subjects (p < 0.01). Furthermore, nociceptin level was significantly higher in the chronic pain group than acute group (p < 0.05). Serum nociceptin level has a relationship with the existence of pain and its duration.

引用

页码：1631 / 1633

页数：3

共 16 条

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