Stem-cell therapies for blood diseases

被引：51

作者：

Bordignon, Claudio ^{[1
]}

机构：

[1] Univ Vita Salute, Ist Sci San Raffaele, I-20132 Milan, Italy

来源：

NATURE | 2006年 / 441卷 / 7097期

关键词：

SEVERE COMBINED IMMUNODEFICIENCY; GENE-THERAPY; BONE-MARROW; TRANSPLANTATION; LYMPHOCYTES;

D O I：

10.1038/nature04962

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

For decades, transplantation of haematopoietic stem cells-either unmodified, or genetically modified to correct genetic disorders-has been used to treat disorders of the blood and immune systems. The present challenge is to reduce the risk of such transplants and increase the number of patients who can safely access this treatment. In developing countries, such 'one-shot' treatments are highly desirable because chronic treatments are difficult to sustain. To make these therapies more accessible and effective it will be important to improve clinical protocols and gene-delivery vectors, and to gain a deeper understanding of stem cells.

引用

页码：1100 / 1102

页数：3

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