Snake venom modulators of platelet adhesion receptors and their ligands

被引:61
作者
Andrews, RK [1 ]
Berndt, MC [1 ]
机构
[1] Baker Med Res Inst, Hazel & Pip Appel Vasc Biol Lab, Melbourne, Vic 8008, Australia
关键词
D O I
10.1016/S0041-0101(99)00187-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In thrombosis, platelet aggregation is initiated by a specific membrane glycoprotein (GP) Ib-IX-V complex binding to its adhesive ligand, von Willebrand factor, in the matrix of ruptured atherosclerotic plaques or in plasma exposed to high hydrodynamic shear stress. This process closely resembles normal haemostasis at high shear, where GP Ib-IX-V-dependent platelet adhesion to von Willebrand factor in the injured blood vessel wall initiates platelet activation and integrin alpha IIb beta 3 (GP IIb-IIIa)-dependent platelet aggregation. At low shear, other receptors such as those that bind collagen, the integrin alpha 2 beta 1 (GP Ia-IIa) or GP VI, mediate platelet adhesion. Recently, snake venom proteins have been identified that selectively modulate platelet function, either promoting or inhibiting platelet aggregation by targeting GP Ib-IX-V, alpha 2 beta 1, GP VI, alpha IIb beta 3, or their respective ligands. Interestingly, these venom proteins typically belong to one of two major protein families, the C-type lectin family or the metalloproteinase-disintegrins. This review focuses on recent insights into structure-activity relationships of snake venom proteins that regulate platelet function, and the ways in which these novel probes have contributed in unexpected ways to our understanding of the molecular mechanisms underlying thrombosis. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:775 / 791
页数:17
相关论文
共 64 条
  • [1] Andrews RK, 1998, HISTOL HISTOPATHOL, V13, P837, DOI 10.14670/HH-13.837
  • [2] Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation
    Andrews, RK
    Kroll, MH
    Ward, CM
    Rose, JW
    Scarborough, RM
    Smith, AI
    Lopez, JA
    Berndt, MC
    [J]. BIOCHEMISTRY, 1996, 35 (38) : 12629 - 12639
  • [3] PURIFICATION OF BOTROCETIN FROM BOTHROPS-JARARACA VENOM - ANALYSIS OF THE BOTROCETIN-MEDIATED INTERACTION BETWEEN VONWILLEBRAND-FACTOR AND THE HUMAN-PLATELET MEMBRANE GLYCOPROTEIN-IB-IX COMPLEX
    ANDREWS, RK
    BOOTH, WJ
    GORMAN, JJ
    CASTALDI, PA
    BERNDT, MC
    [J]. BIOCHEMISTRY, 1989, 28 (21) : 8317 - 8326
  • [4] Molecular mechanisms of platelet adhesion and activation
    Andrews, RK
    Lopez, JA
    Berndt, MC
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1997, 29 (01) : 91 - 105
  • [5] IDENTIFICATION OF ASPARTIC ACID-514 THROUGH GLUTAMIC ACID-542 AS A GLYCOPROTEIN-IB-IX COMPLEX RECEPTOR RECOGNITION SEQUENCE IN VONWILLEBRAND-FACTOR - MECHANISM OF MODULATION OF VONWILLEBRAND-FACTOR BY RISTOCETIN AND BOTROCETIN
    BERNDT, MC
    WARD, CM
    BOOTH, WJ
    CASTALDI, PA
    MAZUROV, AV
    ANDREWS, RK
    [J]. BIOCHEMISTRY, 1992, 31 (45) : 11144 - 11151
  • [6] HEMORRHAGIC METALLOPROTEINASES FROM SNAKE-VENOMS
    BJARNASON, JB
    FOX, JW
    [J]. PHARMACOLOGY & THERAPEUTICS, 1994, 62 (03) : 325 - 372
  • [7] A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    Black, RA
    Rauch, CT
    Kozlosky, CJ
    Peschon, JJ
    Slack, JL
    Wolfson, MF
    Castner, BJ
    Stocking, KL
    Reddy, P
    Srinivasan, S
    Nelson, N
    Boiani, N
    Schooley, KA
    Gerhart, M
    Davis, R
    Fitzner, JN
    Johnson, RS
    Paxton, RJ
    March, CJ
    Cerretti, DP
    [J]. NATURE, 1997, 385 (6618) : 729 - 733
  • [8] Antithrombotic effect of crotalin, a platelet membrane glycoprotein Ib antagonist from venom of Crotalus atrox
    Chang, MC
    Lin, HK
    Peng, HC
    Huang, TF
    [J]. BLOOD, 1998, 91 (05) : 1582 - 1589
  • [9] FUNCTIONAL AND SEQUENCE CHARACTERIZATION OF AGKICETIN, A NEW GLYCOPROTEIN IB ANTAGONIST ISOLATED FROM AGKISTRODON ACUTUS VENOM
    CHEN, YL
    TSAI, IH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 210 (02) : 472 - 477
  • [10] A NOVEL COBRA VENOM METALLOPROTEINASE, MOCARHAGIN, CLEAVES A 10-AMINO ACID PEPTIDE FROM THE MATURE N-TERMINUS OF P-SELECTIN GLYCOPROTEIN LIGAND-RECEPTOR, PSGL-1, AND ABOLISHES P-SELECTIN BINDING
    DELUCA, M
    DUNLOP, LC
    ANDREWS, RK
    FLANNERY, JV
    ETTLING, R
    CUMMING, DA
    VELDMAN, M
    BERNDT, MC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) : 26734 - 26737