Palladium-Catalyzed Asymmetric Dearomatization of Naphthalene Derivatives

被引：157

作者：

Garcia-Fortanet, Jorge ^{[1
]}

Kessler, Florian ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 19期

基金：

美国国家卫生研究院;

关键词：

ENANTIOSELECTIVE CONSTRUCTION; OXIDATIVE DEAROMATIZATION; BIRCH REDUCTION; ALKYLATION; ARENES;

D O I：

10.1021/ja9025193

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists.

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页码：6676 / +

页数：3

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