Plasmid-borne AmpC β-lactamases

被引:36
作者
Walther-Rasmussen, J [1 ]
Hoiby, N [1 ]
机构
[1] Natl Univ Hosp, Rigshosp 9301, Dept Clin Microbiol, Copenhagen, Denmark
关键词
AmpC beta-lactamases; plasmid-encoded; phylogeny; dissemination;
D O I
10.1139/W02-039
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Historically, it was thought that ampC genes encoding class C beta-lactamases were located solely on the chromosome but, within the last 12 years, an increasing number of ampC genes have been found on plasmids. These have mostly been acquired by ampC-deficient pathogenic bacteria, which consequently are supplied with new and additional resistance phenotypes. This review discusses the phylogenetic origin of the plasmid-encoded AmpC beta-lactamases, their occurrence, and mode of spread, as well as their hydrolytic properties.
引用
收藏
页码:479 / 493
页数:15
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