Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women

被引：90

作者：

Munoz, N.

Hernandez-Suarez, G. ^{[1
]}

Mendez, F. ^{[2
]}

Molano, M.

Posso, H.

Moreno, V. ^{[3
]}

Murillo, R.

Ronderos, M.

Meijer, C. ^{[4
]}

Munoz, A. ^{[5
]}

机构：

[1] Inst Nacl Cancerol, Grp Invest Epidemiol, Subdirecc Invest & Salud Publ, Bogota, Colombia

[2] Univ Valle, Escuela Salud Publ, Cali, Colombia

[3] Inst Catalan Oncol, Canc Epidemiol Serv, Barcelona, Spain

[4] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 07期

关键词：

human papillomavirus; persistence; risk; cervical intraepithelial neoplasia; HUMAN-PAPILLOMAVIRUS INFECTION; NATURAL-HISTORY; VIRAL LOAD; YOUNG-WOMEN; DURATION; DETERMINANTS; HUMAN-PAPILLOMAVIRUS-16; CLASSIFICATION; CLEARANCE; LESIONS;

D O I：

10.1038/sj.bjc.6604972

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women > 30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.

引用

页码：1184 / 1190

页数：7

共 37 条

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