Stevens-Johnson syndrome after treatment with STI571: a case report

被引：83

作者：

Hsiao, LT

Chung, HM

Lin, JT

Chiou, TJ

Liu, JH

Fan, FS

Wang, WS

Yen, CC

Chen, PM

机构：

[1] Taipei Vet Gen Hosp, Dept Med, Div Med Oncol, Taipei 112, Taiwan

[2] Taipei Vet Gen Hosp, Dept Dermatol, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 117卷 / 03期

关键词：

chronic myeloid leukaemia; skin; Stevens-Johnson syndrome; STI571; tyrosine kinase inhibitor;

D O I：

10.1046/j.1365-2141.2002.03499.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Between seven and 21% of patients treated with the specific tyrosine kinase inhibitor STI571 have been reported to develop mild-to-moderate severity of adverse cutaneous reactions. We report a patient in the blast crisis phase of chronic myeloid leukaemia who developed a life-threatening cutaneous reaction, Stevens-Johnson syndrome, following 1 week of STI571 therapy. This report may serve to remind the clinician about the possible severe cutaneous side-effects of STI571 before instituting more extensive clinical application of this agent in the future.

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页码：620 / 622

页数：3

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