Keeping transcriptional activators under control

被引：96

作者：

Kodadek, Thomas

Sikder, Devanjan

Nalley, Kip

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

来源：

CELL | 2006年 / 127卷 / 02期

关键词：

D O I：

10.1016/j.cell.2006.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.

引用

收藏

页码：261 / 264

页数：4

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