The PYRIN connection: Novel players in innate immunity and inflammation

被引：93

作者：

Stehlik, C

Reed, JC

机构：

[1] W Virginia Univ, Sch Med, Mary Babb Randolph Canc Ctr, Morgantown, WV 26506 USA

[2] W Virginia Univ, Sch Med, Dept Microbiol Immunol & Cell Biol, Morgantown, WV 26506 USA

[3] Burnham Inst, La Jolla, CA 92037 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 200卷 / 05期

关键词：

D O I：

10.1084/jem.20032234

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.

引用

页码：551 / 558

页数：8

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