Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone

被引:50
作者
Stagliano, Kenneth W.
Emadi, Ashkan
Lu, Zhenhai
Malinakova, Helena C.
Twenter, Barry
Yu, Min
Holland, Louis E.
Rom, Amanda M.
Harwood, John S.
Amin, Ronak
Johnson, Allison A.
Pommier, Yves [1 ]
机构
[1] NCI, Mol Pharmacol Lab, Canc Res Ctr, NIH, Bethesda, MD 20892 USA
[2] IIT, Dept Biol Chem & Phys Sci, Chicago, IL 60616 USA
[3] IIT, Res Inst, Chicago, IL 60616 USA
[4] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
关键词
biquinones and trimeric quinones; HIV-1 integrase inhibitor; regiocontrolled synthesis; conocurvone;
D O I
10.1016/j.bmc.2006.04.034
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Unsymmetrical biquinone and trimeric quinone derivatives were synthesized using halotriflate-biselectrophilic naphthoquinones through stepwise regioselective quinone substitution chemistry and evaluated for their ability to inhibit the cytopathogenic effects of HIV-1 using an MTT colorimetric assay. Compounds were also screened for their ability to inhibit the activity of HIV-1 integrase in vitro. Pyranylated trimeric quinones and biquinones exhibited both antiviral activity and integrase inhibitory activity. Conocurvone 1 and trimeric quinone 21 were the most potent HIV integrase inhibitors in the series. All of the biquinones showed HIV inhibitory activity. Simple methoxy substituted biquinones did not inhibit HIV-1 integrase. Published by Elsevier Ltd.
引用
收藏
页码:5651 / 5665
页数:15
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