Genome duplication strikes back

被引：39

作者：

Spring, J ^{[1
]}

机构：

[1] Univ Basel, Bioctr, Pharmactr, Inst Zool, CH-4056 Basel, Switzerland

来源：

NATURE GENETICS | 2002年 / 31卷 / 02期

关键词：

D O I：

10.1038/ng0602-128

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human genome contains up to four paralogs of many Drosophila genes. Two rounds of whole-genome duplication followed by substantial gene loss could explain this pattern easily, but this hypothesis has often been questioned. Mounting evidence from the human genome sequence now confirms at least one genome duplication during early chordate evolution.

引用

页码：128 / 129

页数：2

共 18 条

[1] Evidence of en bloc duplication in vertebrate genomes [J].

Abi-Rached, L ;

Gilles, A ;

Shiina, T ;

Pontarotti, P ;

Inoko, H .

NATURE GENETICS, 2002, 31 (01) :100-105

[2] The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster [J].

Brooke, NM ;

Garcia-Fernàndez, J ;

Holland, PWH .

NATURE, 1998, 392 (6679) :920-922

[3] Pattern and timing of gene duplication in animal genomes [J].

Friedman, R ;

Hughes, AL .

GENOME RESEARCH, 2001, 11 (11) :1842-1847

[4] Age distribution of human gene families shows significant roles of both large- and small-scale duplications in vertebrate evolution [J].

Gu, X ;

Wang, YF ;

Gu, JY .

NATURE GENETICS, 2002, 31 (02) :205-209

[5]

HOLLAND PWH, 1994, DEVELOPMENT, P125

[6] Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[7] The evolutionary fate and consequences of duplicate genes [J].

Lynch, M ;

Conery, JS .

SCIENCE, 2000, 290 (5494) :1151-1155

[8]

Matzke MA, 1999, BIOESSAYS, V21, P761, DOI 10.1002/(SICI)1521-1878(199909)21:9&lt

[9]

761::AID-BIES7&gt

[10]

3.0.CO

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