Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages

被引：236

作者：

McGovern, Naomi ^{[1
,2
]}

Schlitzer, Andreas ^{[2
]}

Gunawan, Merry ^{[1
]}

Jardine, Laura ^{[1
]}

Shin, Amanda ^{[2
]}

Poyner, Elizabeth ^{[1
]}

Green, Kile ^{[1
]}

Dickinson, Rachel ^{[1
]}

Wang, Xiao-nong ^{[1
]}

Low, Donovan ^{[2
]}

Best, Katie ^{[1
]}

Covins, Samuel ^{[1
]}

Milne, Paul ^{[1
]}

Pagan, Sarah ^{[1
]}

Aljefri, Khadija ^{[1
]}

Windebank, Martin ^{[1
]}

Saavedra, Diego Miranda ^{[1
]}

Larbi, Anis ^{[2
]}

Wasan, Pavandip Singh ^{[1
]}

Duan, Kaibo ^{[2
]}

Poidinger, Michael ^{[2
,3
]}

Bigley, Venetia ^{[1
]}

Ginhoux, Florent ^{[2
]}

Collin, Matthew ^{[1
]}

Haniffa, Muzlifah ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] ASTAR, Singapore Immunol Network, Singapore 138648, Singapore

[3] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

来源：

IMMUNITY | 2014年 / 41卷 / 03期

基金：

英国惠康基金;

关键词：

CD8-ALPHA(+) DENDRITIC CELLS; ANTIGEN-PRESENTING CELLS; STEADY-STATE; FUNCTIONAL SPECIALIZATION; TISSUE MACROPHAGES; LANGERHANS CELLS; MOUSE; SKIN; DIFFERENTIATION; REVEALS;

D O I：

10.1016/j.immuni.2014.08.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi) XCR1(+)CLEC9A(+) DCs and CD1c(+) DCs are murine CD103(+) DCs and CD64(-)CD11b(+) DCs. In addition, human tissues also contain CD14(+) cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14(+) cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of <6 days. The decline and reconstitution kinetics of human blood CD14(+) monocytes and dermal CD14(+) cells in vivo supported their precursor-progeny relationship. The murine homologs of human dermal CD14(+) cells are CD11b(+) CD64(+) monocyte-derived macrophages. Human and mouse monocytes and macrophages were defined by highly conserved gene transcripts, which were distinct from DCs. The demonstration of monocyte-derived macrophages in the steady state in human tissue supports a conserved organization of human and mouse mononuclear phagocyte system.

引用

页码：465 / 477

页数：13

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