Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction

被引:65
作者
Baylin, Ana
Hernandez-Diaz, Sonia
Kabagambe, Edmond K.
Siles, Xinia
Campos, Hannia
机构
[1] Brown Univ, Dept Community Hlth, Providence, RI 02912 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Cambridge, MA 02138 USA
[4] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA
关键词
D O I
10.1097/01.ede.0000229444.55718.96
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: The effects of coffee on myocardial infarction are uncertain. We hypothesize that coffee in the presence of predisposing factors can induce a cascade of events that, through sympathetic nervous activation, can induce the onset of myocardial infarction. Methods: We recruited 503 incident cases of nonfatal myocardial infarction between 1994 and 1998 in Costa Rica. We used a case-crossover design to calculate relative risks (RRs) and 95% confidence intervals (95% CIs). Results: The RR of myocardial infarction in the hour after coffee intake was 1.49 (95% CI = 1.17-1.89). Occasional coffee drinkers (<= 1 cup/day, n = 103) had a RR of myocardial infarction of 4.14 (2.03-8.42), moderate coffee drinkers (2-3 cups/day, n = 280) had a RR of 1.60 (1.16-2.21), and heavy coffee drinkers (>= 4 cups/d, n = 120) had a RR of, 1.06 (0.69-1.63; P = 0.006, test of homogeneity). Patients with 3 or more risk factors (n = 101) had a RR of myocardial infarction of 2.10 (1.30-3.39), whereas patients with fewer than 3 risk factors (n = 396) had a RR of 1.39 (1.04-1.82; P = 0.15, test of homogeneity); and RR was 1.72 (1.30-2.30) among sedentary patients compared with 1.07 (0.66 - 1.72) among nonsedentary (P = 0.10, test of homogeneity). Conclusions: The findings indicate that coffee intake may trigger myocardial infarction. The association is particularly strong among people with light/occasional intake of coffee (51 cup/day), with sedentary lifestyle, or with 3 or more risk factors for coronary heart disease.
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收藏
页码:506 / 511
页数:6
相关论文
共 35 条
[1]  
American Diabetes Association, 1998, DIABETES CARE S1, V21, ps5
[2]  
[Anonymous], 2000, CAMBRIDGE WORLD HIST
[3]   Adipose tissue biomarkers of fatty acid intake [J].
Baylin, A ;
Kabagambe, EK ;
Siles, X ;
Campos, H .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (04) :750-757
[4]   Adipose tissue α-linolenic acid and nonfatal acute myocardial infarction in Costa Rica [J].
Baylin, A ;
Kabagambe, EK ;
Ascherio, A ;
Spiegelman, D ;
Campos, H .
CIRCULATION, 2003, 107 (12) :1586-1591
[5]   Definition and prevalence of sedentarism in an urban population [J].
Bernstein, MS ;
Morabia, A ;
Sloutskis, D .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1999, 89 (06) :862-867
[6]   THE ABSOLUTE BIOAVAILABILITY OF CAFFEINE IN MAN [J].
BLANCHARD, J ;
SAWERS, SJA .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 24 (01) :93-98
[7]  
Bolumar F, 1997, AM J EPIDEMIOL, V145, P324, DOI 10.1093/oxfordjournals.aje.a009109
[8]   Siesta and the risk of coronary heart disease: results from a population-based, case-control study in Costa Rica [J].
Campos, H ;
Siles, X .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2000, 29 (03) :429-437
[9]   Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content -: Role of habitual versus nonhabitual drinking [J].
Corti, R ;
Binggeli, C ;
Sudano, I ;
Spieker, L ;
Hänseler, E ;
Ruschitzka, F ;
Chaplin, WF ;
Lüscher, TF ;
Noll, G .
CIRCULATION, 2002, 106 (23) :2935-2940
[10]  
Elliott William J., 2001, American Journal of Hypertension, V14, p291S, DOI 10.1016/S0895-7061(01)02174-4