A chondroitin sulfate small molecule that stimulates neuronal growth

被引：136

作者：

Tully, SE ^{[1
]}

Mabon, R ^{[1
]}

Gama, CI ^{[1
]}

Tsai, SM ^{[1
]}

Liu, XW ^{[1
]}

Hsieh-Wilson, LC ^{[1
]}

机构：

[1] CALTECH, Dept Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 25期

关键词：

D O I：

10.1021/ja0484045

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity. Copyright © 2004 American Chemical Society.

引用

页码：7736 / 7737

页数：2

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