Cardiovascular Metabolomics

被引：320

作者：

McGarrah, Robert W. ^{[1
,2
,3
,5
]}

Crown, Scott B. ^{[1
,2
]}

Zhang, Guo-Fang ^{[1
,2
,4
,5
]}

Shah, Svati H. ^{[1
,2
,3
,5
]}

Newgard, Christopher B. ^{[1
,2
,4
,5
,6
,7
]}

机构：

[1] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC USA

[2] Duke Univ, Med Ctr, Duke Mol Physiol Inst, 300 N Duke St, Durham, NC 27701 USA

[3] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Div Endocrinol, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[6] Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA

[7] Duke Univ, Med Ctr, Dept Canc Biol, Durham, NC 27710 USA

来源：

CIRCULATION RESEARCH | 2018年 / 122卷 / 09期

基金：

美国国家卫生研究院;

关键词：

amino acids; cardiovascular diseases; heart failure; ketone bodies; metabolism; MYOCARDIAL SUBSTRATE METABOLISM; TRIMETHYLAMINE-N-OXIDE; FATTY-ACID OXIDATION; CHAIN AMINO-ACIDS; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; HUMAN HEART-FAILURE; IN-VIVO ASSESSMENT; MASS-SPECTROMETRY; GLUCOSE-METABOLISM;

D O I：

10.1161/CIRCRESAHA.117.311002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studies have contributed to better understanding of the metabolic changes that occur in heart failure and ischemic heart disease and have identified new cardiovascular disease biomarkers. As technologies advance, the metabolomics field continues to evolve rapidly. In this review, we will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolomics to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field.

引用

页码：1238 / 1258

页数：21

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