REVIEW PAPER: The Role of Inflammation in Mouse Pulmonary Neoplasia

被引：17

作者：

Bauer, A. K. ^{[1
]}

Rondini, E. A. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Pathobiol & Diagnost Invest, Ctr Integrat Toxicol, E Lansing, MI 48824 USA

来源：

VETERINARY PATHOLOGY | 2009年 / 46卷 / 03期

关键词：

Genetic susceptibility; inflammation; knockout; mice; neoplasia; pharmacologic; pulmonary; transgenic; CELL LUNG-CANCER; NF-KAPPA-B; REGULATORY T-CELLS; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; FEMALE A/J MICE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BUTYLATED HYDROXYTOLUENE BHT; ACTIVATED-RECEPTOR-GAMMA; INTERFERON-GAMMA;

D O I：

10.1354/vp.08-VP-0217-B-REV

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Inflammation is a risk factor for the development of many types of neoplasia, including skin, colon, gastric, and mammary cancers, among others. Chronic pulmonary diseases, such as chronic bronchitis and asthma, predispose to lung neoplasia. We will review the mouse literature examining the role of inflammation in lung neoplasia, focusing specifically on genetic susceptibility, pharmacologic modulation of inflammatory pathways, and both transgenic and knockout mouse models used to assess pro- and anti-inflammatory pathways involved in lung neoplasia. Identification of molecular mechanisms that govern the association between inflammation and pulmonary neoplasia could provide novel preventive, diagnostic, and therapeutic strategies for a disease in which few biomarkers currently exist.

引用

页码：369 / 390

页数：22

共 211 条

[1]

The CXC chemokine, monokine induced by interferon-γ, inhibits non-small cell lung carcinoma tumor growth and metastasis [J].

Addison, CL ;

Arenberg, DA ;

Morris, SB ;

Xue, YY ;

Burdick, MD ;

Mulligan, MS ;

Iannettoni, MD ;

Strieter, RM .

HUMAN GENE THERAPY, 2000, 11 (02) :247-261

[2]

Blocking oncogenic Ras signaling for cancer therapy [J].

Adjei, AA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (14) :1062-1074

[3]

ADRIAENSSENS PI, 1983, CANCER RES, V43, P4762

[4]

Signalling pathways of the TNF superfamily: A double-edged sword [J].

Aggarwal, BB .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (09) :745-756

[5]

ALBINA JE, 2000, BIOL PATHOBIOLOGY, P711

[6]

Almawi WY, 2002, J LEUKOCYTE BIOL, V71, P9

[7]

Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT) (Withdrawn Publication. See vol. 28, pg. 2426, 2007) [J].

Alyaqoub, Fadel S. ;

Tao, Lianhui ;

Kramer, Paula M. ;

Steele, Vernon E. ;

Lubet, Ronald A. ;

Gunning, William T. ;

Pereira, Michael A. .

CARCINOGENESIS, 2007, 28 (01) :124-129

[8]

Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT) [J].

Alyaqoub, Fadel S. ;

Tao, Lianhui ;

Kramer, Paula M. ;

Steele, Vernon E. ;

Lubet, Ronald A. ;

Gunning, William T. ;

Pereira, Michael A. .

CARCINOGENESIS, 2006, 27 (12) :2442-2447

[9]

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[10]

Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases [J].

Arenberg, DA ;

Kunkel, SL ;

Polverini, PJ ;

Morris, SB ;

Burdick, MD ;

Glass, MC ;

Taub, DT ;

Iannettoni, MD ;

Whyte, TI ;

Strieter, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :981-992

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