Calcium signalling: How do IP3 receptors work?

被引:39
作者
Dawson, AP
机构
关键词
D O I
10.1016/S0960-9822(06)00277-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The intracellular receptor for inositol 1,4,5-trisphosphate (IP3) is responsible for generation and control of very complex Ca2+ signals, New experimental approaches to studying the kinetics of the IP3 receptor are now beginning to give same insight into the mechanisms behind its rather bizarre properties.
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页码:R544 / R547
页数:4
相关论文
共 14 条
[1]   Elementary and global aspects of calcium signalling [J].
Berridge, MJ .
JOURNAL OF PHYSIOLOGY-LONDON, 1997, 499 (02) :291-306
[2]   Inositol 1,4,5-trisphosphate and calcium regulate the calcium channel function of the hepatic inositol 1,4,5-trisphosphate receptor [J].
Dufour, JF ;
Arias, IM ;
Turner, TJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (05) :2675-2681
[3]   CALCIUM AS A COAGONIST OF INOSITOL 1,4,5-TRISPHOSPHATE INDUCED CALCIUM RELEASE [J].
FINCH, EA ;
TURNER, TJ ;
GOLDIN, SM .
SCIENCE, 1991, 252 (5004) :443-446
[4]   THE INOSITOL TRISPHOSPHATE CALCIUM-CHANNEL IS INACTIVATED BY INOSITOL TRISPHOSPHATE [J].
HAJNOCZKY, G ;
THOMAS, AP .
NATURE, 1994, 370 (6489) :474-477
[5]  
HIROSE K, 1994, NATURE, V372, P791
[6]   KINETICS OF CALCIUM-RELEASE BY IMMUNOAFFINITY-PURIFIED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RECONSTITUTED LIPID VESICLES [J].
HIROTA, J ;
MICHIKAWA, T ;
MIYAWAKI, A ;
FURUICHI, T ;
OKURA, I ;
MIKOSHIBA, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (32) :19046-19051
[7]   Elementary calcium-release units induced by inositol trisphosphate [J].
Horne, JH ;
Meyer, T .
SCIENCE, 1997, 276 (5319) :1690-1693
[8]   QUANTAL CA-2+ RELEASE AND THE CONTROL OF CA-2+ ENTRY BY INOSITOL PHOSPHATES - A POSSIBLE MECHANISM [J].
IRVINE, RF .
FEBS LETTERS, 1990, 263 (01) :5-9
[9]   Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity [J].
Marchant, JS ;
Taylor, CW .
CURRENT BIOLOGY, 1997, 7 (07) :510-518
[10]   KINETICS OF CALCIUM-CHANNEL OPENING BY INOSITOL 1,4,5-TRISPHOSPHATE [J].
MEYER, T ;
WENSEL, T ;
STRYER, L .
BIOCHEMISTRY, 1990, 29 (01) :32-37