Anti-Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome

被引：47

作者：

Le Quintrec, M. ^{[1
,2
]}

Zuber, J. ^{[1
,2
]}

Noel, L. -H. ^{[1
,3
]}

Thervet, E. ^{[1
,2
]}

Fremeaux-Bacchi, V. ^{[1
,4
]}

Fridman, W. -H. ^{[1
,4
]}

Legendre, C. ^{[1
,2
]}

Dragon-Durey, M. -A. ^{[1
,4
]}

机构：

[1] Univ Paris 05, Paris, France

[2] Hop Necker Enfants Malad, AP HP, Serv Transplantat Renale & Soins Intensifs, Paris, France

[3] Hop Necker Enfants Malad, AP HP, Serv Anatomopathol, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Serv Immunol Biol, Paris, France

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2009年 / 9卷 / 05期

关键词：

MUTATIONS; HUS; RECURRENCE; IMPACT; GENE; CFH;

D O I：

10.1111/j.1600-6143.2009.02586.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Hemolytic uremic syndrome (HUS) associated with anti-Factor H (anti-FH) autoantibodies is a recently described pathophysiological entity. Monitoring of anti-FH IgG titer may be a sensitive marker of disease activity and guide treatment to eliminate circulating anti-FH antibodies. We report here a case of atypical HUS (aHUS) in which anti-FH autoantibodies were detected during the course of a fifth kidney transplant, 30 years after the first flare of aHUS. This exceptional case suggests that early, specific management based on immunosuppressive therapy and plasma exchanges monitored by anti-FH IgG titer may result in long-term graft survival.

引用

页码：1223 / 1229

页数：7

共 18 条

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