TiCl4 mediated LiBH4 reduction of beta-ketophosphine oxides: A high stereoselective route to the synthesis of anti-beta-hydroxyphosphine oxides

被引：22

作者：

Bartoli, G ^{[1
]}

Bosco, M ^{[1
]}

Sambri, L ^{[1
]}

Marcantoni, E ^{[1
]}

机构：

[1] DIPARTIMENTO SCI CHIM,I-62032 CAMERINO,ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 41期

关键词：

D O I：

10.1016/0040-4039(96)01601-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reduction of an alpha-alkyl-beta-kerophosphine oxide with LiBH4 in presence of a strong chelating agent, such as TiCl4, gives the corresponding beta-hydroxyphosphine oxide in high yields and with high anti-diastereoselectivity independently from the size of both the alpha- and beta-alkyl chains. Copyright (C) 1996 Elsevier Science Ltd

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页码：7421 / 7424

页数：4

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